Bakopa monnieri, e tsejoang hape e le brahmi ka Sanskrit le tonic ea boko ka Senyesemane, ke setlama se sebelisoang hangata sa Ayurvedic. Tlhahlobo e ncha ea saense e bolela hore setlama sa Indian Ayurvedic Bacopa monnieri se bontšitsoe ho thusa ho thibela lefu la Alzheimer's (AD). Tlhahlobo, e hatisitsoeng koranteng ea Science Drug Target Insights, e entsoe ke sehlopha sa bafuputsi ba Malaysia ba tsoang Univesithing ea Taylor United States 'me ba hlahloba liphello tsa bophelo bo botle ba li-bacosides, karolo ea bioactive ea semela sena.
Ha ba bua ka lithuto tse peli tse entsoeng ka 2011, bafuputsi ba boletse hore li-bacosides li ka sireletsa boko ho senyeha ha oxidative le ho fokotseha ha kelello ho amanang le lilemo ka mekhoa e mengata. Joalo ka glycoside e seng polar, li-bacosides li ka tšela mokoallo oa mali le boko ka phallo e bonolo ea lipid-mediated passive diffusion. Ho ipapisitsoe le liphuputso tse fetileng, bafuputsi ba boletse hore li-bacosides le tsona li ka ntlafatsa ts'ebetso ea kelello ka lebaka la thepa ea eona ea mahala ea scavenging.
Melemo e meng ea bophelo bo botle eali-bacosideskenyeletsa ho sireletsa li-neurone ho tsoa ho chefo e bakoang ke Aβ, peptide e phethang karolo ea bohlokoa ho pathogenesis ea AD hobane e ka bokana ho insoluble amyloid fibrils. Tlhahlobo ena e senola lits'ebetso tse sebetsang tsa Bacopa monnieri ts'ebetsong ea ts'ebetso ea kelello le ea methapo ea kutlo, 'me li-phytoconstituents tsa eona li ka sebelisoa bakeng sa nts'etsopele ea meriana e mecha.Limela tse ngata tsa setso li na le metsoako e rarahaneng ea metsoako e nang le mesebetsi e fapaneng ea meriana le ea likokoana-hloko, haholo-holo Bacopa monnieri, e sebelisoang. joalo ka meriana ea setso le nts'etsopele ea lihlahisoa tse thibelang botsofali.
● Melemo e Tšeletseng eaBakopa Monnieri
1.E ntlafatsa mohopolo le kutloisiso
Bacopa e na le melemo e mengata e hohelang, empa mohlomong e tsebahala haholo ka bokhoni ba eona ba ho ntlafatsa mohopolo le temoho. Mokhoa o ka sehloohong oo ka oonaBakopae ntlafatsa mohopolo le temoho ke ka puisano e ntlafalitsoeng ea synaptic. Ka ho khetheha, setlama se khothalletsa ho hōla le ho ata ha dendrites, e leng ho matlafatsang matšoao a methapo.
Tlhokomeliso: Li-dendrites ke li-extensions tsa lisele tsa methapo tse kang lekala tse amohelang matšoao a kenang, kahoo ho matlafatsa "lithapo" tsena tsa puisano ea tsamaiso ea methapo qetellong ho matlafatsa ts'ebetso ea kelello.
Liphuputso li fumane hore Bacoside-A e susumetsa lisele tsa methapo, ho etsa hore li-synapse li amohele maikutlo a kenang a methapo. Bacopa e boetse e bonts'itsoe ho ntlafatsa mohopolo le temoho ka ho susumetsa ts'ebetso ea hippocampal ka ho eketsa ts'ebetso ea protheine kinase 'meleng, e tsamaisang litsela tse fapaneng tsa cellular.
Kaha hippocampus e bohlokoa hoo e ka bang mesebetsing eohle ea kelello, bafuputsi ba lumela hore ena ke e 'ngoe ea litsela tsa mantlha tseo Bacopa e ntlafatsang matla a kelello.
Liphuputso tse ling li bontšitse hore tlatsetso ea letsatsi le letsatsi leBakopa monnieri(ka litekanyetso tsa 300-640 mg ka letsatsi) e ka ntlafala:
Mohopolo o sebetsang
Mehopolo ea sebaka
Mohopolo o sa tsebeng
Tlhokomeliso
Sekhahla sa ho ithuta
Ho kopanya mohopolo
Mosebetsi oa ho hopola o liehile
Ho hopola mantsoe
Mohopolo wa pono
2.E Fokotsa Khatello ea Maikutlo le Matšoenyeho
Ebang ke tsa lichelete, tsa kahisano, tsa ’mele, tsa kelello, kapa tsa maikutlo, khatello ea kelello ke taba e ka sehloohong bophelong ba batho ba bangata. Hona joale ho feta leha e le neng pele, batho ba batla ho baleha ka mekhoa leha e le efe e hlokahalang, ho akarelletsa lithethefatsi le joala. Leha ho le joalo, lintho tse kang lithethefatsi le joala li ka ba le liphello tse mpe kelellong le ’meleng oa motho.
U ka ’na ua thahasella ho tseba seoBakopae na le histori e telele ea ho sebelisoa e le tsamaiso ea methapo ea kutlo ho imolla maikutlo a ho tšoenyeha, ho tšoenyeha, le khatello ea kelello. Sena se bakoa ke thepa ea adaptogenic ea Bacopa, e matlafatsang matla a 'mele ea rona ea ho sebetsana ka katleho le, ho sebelisana le, le ho hlaphoheloa khatellong ea maikutlo (kelello,' mele). , le maikutlo). Bacopa e na le litšobotsi tsena tse ikamahanyang le maemo ka karolo e itseng ka lebaka la taolo ea eona ea li-neurotransmitters, empa setlama sena sa khale se boetse se ama maemo a cortisol.
Joalokaha u ka tseba, cortisol ke hormone e ka sehloohong ea khatello ea kelello 'meleng. Khatello ea kelello e sa foleng le maemo a phahameng a cortisol a ka senya boko ba hau.Ha e le hantle, litsebi tsa methapo ea kutlo li fumane hore khatello ea kelello e sa foleng e ka baka liphetoho tsa nako e telele mohahong oa boko le mosebetsi, e leng se lebisang ho feteletseng ha liprotheine tse itseng tse senyang li-neurone.
Khatello ea kelello e sa feleng e boetse e baka tšenyo ea oxidative ho li-neuron, e ka bang le litlamorao tse fapaneng tse mpe, ho kenyelletsa:
Ho lahleheloa ke mohopolo
Ho shoa ha lisele tsa neuron
Ho se sebetse hantle ha liqeto
Atrophy ea boima ba boko.
Bacopa monnieri e na le thepa e matla ea ho imolla khatello ea maikutlo, e sireletsang methapo ea kutlo. Lithuto tsa batho li ngotse litlamorao tsa adaptogenic tsa Bacopa monnieri, ho kenyelletsa le ho fokotsa cortisol. Cortisol e tlase e lebisa ho fokotseng maikutlo a khatello ea maikutlo, a ke keng a ntlafatsa maikutlo feela, empa hape a eketsa ho tsepamisa maikutlo le tlhahiso. Ho feta moo, hobane Bacopa monnieri e laola dopamine le serotonin, e ka fokotsa liphetoho tse bakoang ke khatello ea kelello ho dopamine le serotonin ka hippocampus le prefrontal cortex, e hatisa ho feta makhabane a adaptogenic a setlama sena.
Bakopa monnierie boetse e eketsa tlhahiso ea tryptophan hydroxylase (TPH2), e leng enzyme e hlokahalang bakeng sa mesebetsi e sa tšoaneng ea tsamaiso ea methapo e bohareng, ho akarelletsa le serotonin synthesis. Habohlokoa le ho feta, bacoside-A, e leng e 'ngoe ea metsoako e ka sehloohong e sebetsang ho Bacopa monnieri, e bontšitsoe ho matlafatsa ts'ebetso ea GABA. GABA ke neurotransmitter e khutsitseng, e thibelang motho. Bacopa monnieri e ka phahamisa ts'ebetso ea GABA le ho fokotsa ts'ebetso ea glutamate, e ka thusang ho fokotsa maikutlo a ho tšoenyeha ka ho fokotsa ts'ebetso ea li-neurone tse ka 'nang tsa e-ba overstimulated. -e ntle” vibe.
Nako ea poso: Oct-08-2024
